Respiratory Question #38


Isoniazid is prescribed to a client with tuberculosis. How will the nurse instruct the client to take the medication?


  1. Take the medication with the evening meal for best absorption.
    • Rationale:
  2. Take the medication with antacids to relieve GI upset.
    • Rationale:
  3. Take the medication 30 minutes following the first meal of the day.
    • Rationale:
  4. Take the medication on an empty stomach.
    • Rationale:



Isoniazid should be taken on an empty stomach. Food would interfere with absorption and antacids affect the medication (by decreasing its effectiveness) and the medication should be taken 1 hour prior to food or 2 hours following food intake.

Learning Outcomes

Test Taking Tip

Video Rationale