Respiratory Question #22


The nurse will provide teaching on side effects of rifampin, isoniazid, and ethambutol to a client with tuberculosis. These medications will have which adverse reactions? (Select all that apply)


  1. Isoniazid may cause dark urine and yellowing of the skin.
    • Rationale:
  2. Ethambutol causes contact lenses to be stained orange.
    • Rationale:
  3. Rifampin causes contact lenses to become stained orange.
    • Rationale:
  4. Ethambutol may cause visual disturbances.
    • Rationale:



Drugs used to treat tuberculosis include isoniazid, rifampin, and ethambutol. Each has specific adverse effects that should be shared with all clients. Isoniazid may cause yellowing of the skin or darkened urine since 10-20% of persons taking the drug will develop elevated liver function values. Ethambutol may cause optic neuritis including symptoms of blurred vision, spots in field of vision, or red/green color blindness. Rifampin may cause excretion of orange color in body fluids including tears, which may cause contact lenses to be orange-stained. Ethambutol does not cause contact lenses to stain orange (selection B is therefore incorrect).

Learning Outcomes

Test Taking Tip

Video Rationale