Pharmacology TB Drugs #4

Question

Which lab(s) are most important to check during treatment with rifampin?

Answers

  1. B6 levels
    • Rationale:

      This answer is not correct because the importance of taking B6 (pyridoxine) due to the risk of deficiency and subsequent peripheral neuropathy is related to isoniazid (INH) therapy for TB. B6 levels are not decreased with rifampin therapy.

  2. AST/ALT
    • Rationale:

      This answer is correct because AST/ALT blood levels reflect liver function and should be monitored to help anticipate and prevent any unnecessary risks. Rifampin is very toxic to the liver so monitoring signs and symptoms of liver failure along with liver function blood tests is very important.

  3. Creatinine
    • Rationale:

      This answer is not correct because creatinine levels reflect kidney function. Creatinine is not the most important blood level to monitor. Rifampin is toxic to the liver so periodic liver function blood tests, such as AST and ALT, are extremely important.

  4. WBC/RBC
    • Rationale:

      This answer is not correct because white blood cell levels (WBC) and red blood cell levels (RBC) are not the most important blood tests when a patient is taking rifampin. Rifampin is toxic to the liver so periodic liver function blood tests, such as AST and ALT, are extremely important.

Overview

Rifampin is one of the antibiotics used to treat tuberculosis (TB). This medication is very toxic to the liver so liver function tests, such as AST and ALT blood tests are necessary.

Explanation

Learning Outcomes

Tuberculosis (TB) is caused by the mycobacterium tuberculosis bacteria and can cause serious infection in the body that mostly affects the lungs. Rifampin is one of the antibiotics used to treat tuberculosis (TB). This medication is very toxic to the liver so liver function tests, such as AST and ALT blood tests are necessary. Periodic blood tests will be taken to check the function of the liver during treatment with those antibiotics to help anticipate and prevent any unnecessary risks.

Test Taking Tip

Tell yourself during the exam, “I can do this! If I am not sure, I can figure this out!” Positive, encouraging self-talk helps during nursing examinations.

Video Rationale