Pharmacology Question #87

Question

A patient is prescribed a COX-2 inhibitor for arthritis and the nurse is instructing the patient on which COX-2 inhibitor?

Answers

  1. Celecoxib
    • Rationale:

      This answer is correct because celecoxib is a type of nonsteroidal anti-inflammatory medication called a COX-2 inhibitor. A COX-2 inhibitor focuses it’s action of cyclooxygenase-2, an enzyme substance in the body responsible for pain and inflammation. Due to this targeted selectively of COX-2 inhibitors, peptic ulcer risk is reduced. COX-2 inhibitors such as celecoxib, is associated with increased risk of cardiovascular disease and stroke, so the nurse will instruct on reporting signs of stroke, chest pain, dyspnea, dizziness, or confusion.

  2. Ibuprofen
    • Rationale:

      This answer is not correct because ibuprofen is an NSAID but is not a COX-2 inhibitor. A COX-2 inhibitor focuses it’s action of cyclooxygenase-2, an enzyme substance in the body responsible for pain and inflammation. Due to this targeted selectively of COX-2 inhibitors, peptic ulcer risk is reduced. Peptic ulceration and bleeding ulcers is a common risk of nonsteroidal anti-inflammatory (NSAID) medications.

  3. Naproxen
    • Rationale:

      This answer is not correct because naproxen is a non-selective COX inhibitor. Naproxen has an increased risk of peptic ulcer risk compared to celecoxib, a COX-2 inhibitor.

  4. Acetaminophen
    • Rationale:

      This answer is not correct because acetaminophen is not an NSAID or a COX-2 inhibitor. There is not the risk of heart attack or stroke with acetaminophen, but taking too much acetaminophen can produce liver toxicity.

Overview

Celecoxib is a COX-2 inhibitor prescribed for arthritis.

Explanation

Learning Outcomes

Celecoxib is a type of nonsteroidal anti-inflammatory medication called a COX-2 inhibitor. A COX-2 inhibitor focuses it’s action of cyclooxygenase-2, an enzyme substance in the body responsible for pain and inflammation. Due to this targeted selectively of COX-2 inhibitors, peptic ulcer risk is reduced. Peptic ulceration and bleeding ulcers is a common risk of nonsteroidal anti-inflammatory (NSAID) medications. COX-2 inhibitors such as celecoxib, is associated with increased risk of cardiovascular disease and stroke, so the nurse will instruct on reporting signs of stroke, chest pain, dyspnea, dizziness, or confusion.

Test Taking Tip

Anxiety in the time leading up to an exam is normal. Reduce your stress by studying often, not long. Spend at least 15 minutes every day reviewing the “old” material. This action alone will greatly reduce anxiety. The more time you devote to reviewing past material, the more confident you will feel about your knowledge of the topics. Start this review process on the first day of the semester. Don’t wait until the middle to end of the semester to try to cram information.

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