Pharmacology TB Drugs #6

Question

Isoniazid is prescribed to a patient with tuberculosis. How will the nurse instruct the patient to take the medication?

Answers

  1. Take the medication with the evening meal for best absorption.
    • Rationale:

      This answer is not correct because isoniazid should not be taken but on an empty stomach. Taking the medication with the evening meal will decrease absorption and effectiveness.

  2. Take the medication with antacids to relieve GI upset.
    • Rationale:

      This answer is not correct because isoniazid should not be taken with an antacid, but on an empty stomach. Taking the medication with antacids will decrease absorption and effectiveness.

  3. Take the medication 30 minutes following the first meal of the day.
    • Rationale:

      This answer is not correct because isoniazid should not be taken within 2 hours of food. Best absorption is taking on an empty stomach. It is best to not take isoniazid unless food is ingested 2 hours prior to taking or 2 hours after taking the medication. Taking the medication with food or antacids will decrease absorption and effectiveness.

  4. Take the medication on an empty stomach.
    • Rationale:

      This answer is correct because taking isoniazid on an empty stomach is the best way to take the medication. Food or antacids will decrease absorption and effectiveness of isoniazid. Both should be taken or ingested 2 hours prior to taking isoniazid or 2 hours after taking isoniazid. Isoniazid is a common anti-tuberculosis medication. Effective treatment is imperative since tuberculosis is not only serious for the patient but a risk for the community, if not treated properly.

Overview

Isoniazid is an anti-tuberculosis medication. Patients should be taught to take the medication on an empty stomach to promote adequate absorption to be effective.

Explanation

Isoniazid should be taken on an empty stomach. Food would interfere with absorption and antacids affect the medication (by decreasing its effectiveness) and the medication should be taken 1 hour prior to food or 2 hours following food intake.

Learning Outcomes

Isoniazid is a common anti-tuberculosis medication. Effective treatment is imperative since tuberculosis is not only serious for the patient but a risk for the community, if not treated properly. Isoniazid should be taken on an empty stomach since food would interfere with absorption. Antacids also interfere with isoniazid. Both should be taken or ingested 2 hours prior to taking isoniazid or 2 hours after taking isoniazid.

Test Taking Tip

Antacids interfere with a lot of medications. It is generally safe to separate taking antacids from other medications by 2 hours.

Video Rationale