Pharmacology Diabetes meds #15

Question

A patient is asking the nurse about some of the most common adverse reactions associated with taking glyburide. Which adverse reaction would the nurse emphasize as one of the most common?

Answers

  1. Hypoglycemia
    • Rationale:

      This answer is correct because hypoglycemia is the most common adverse effect associated with glyburide therapy. Studies have indicated that hypoglycemic risk is highest in glyburide compared to other sulfonylurea oral antidiabetic. Hypoglycemia signs and symptoms include dizziness, irritability, confusion, sweating, weakness, and shakiness.

  2. Aplastic anemia
    • Rationale:

      This answer is not correct because aplastic anemia is not a common adverse side effect for glyburide. Aplastic anemia is a rare adverse effect with symptoms including sudden fatigue, multiple infections, and bleeding tendencies.

  3. Liver failure
    • Rationale:

      This answer is not correct because liver failure is not a common adverse side effect for glyburide. Liver failure is a rare adverse effect with symptoms including jaundice, dark urine, increased liver function tests (AST/ALT).

  4. Weight loss
    • Rationale:

      This answer is not correct because weight gain, not weight loss is a common side effect of glyburide. Although weight loss can occur, it is not as common as weight gain.

Overview

Glyburide is an oral antidiabetic medication. The most common adverse side effect is hypoglycemia.

Explanation

Oral medications for Type 2 diabetes may cause lower blood sugar and the nurse must monitor for signs of hypoglycemic reactions such as sweating, hunger, weakness, tremor, tachycardia, and anxiety. The nurse should also evaluate other medications the client may be taking for drug/drug interactions.

Learning Outcomes

Glyburide is an oral antidiabetic medication in the sulfonylurea class. This medication is only effective in helping to control blood glucose levels of the diabetes mellitus type 2 patient. Studies have indicated that hypoglycemic risk is highest in glyburide compared to other sulfonylurea oral antidiabetic. Hypoglycemia signs and symptoms include dizziness, irritability, confusion, sweating, weakness, and shakiness. Other common side effects of glyburide include diarrhea, dizziness, dyspepsia, headache, gas, and weight gain. Rare side effects include aplastic anemia and liver failure.

Test Taking Tip

Remember that when a medication is designed to have a certain action, there is a risk of the medication causing an extreme action. For example, if a medication is being prescribed to lower blood glucose or blood pressure, there is a risk of hypoglycemia and hypotension, respectively.

Video Rationale