Pharmacology Pharmacokinetics #3

Question

Which best describes the drug effect that the nurse is assessing when the nurse asks if the client is taking over-the-counter aspirin before administering the prescribed warfarin?

Answers

  1. Unique effects
    • Rationale:

      This is not the correct answer because the potentiative effects are known for warfarin and aspirin. Unique effects are rare and something that occurs when two drugs are combined and a response occurs not seen when the drugs are given individually. Both warfarin and aspirin individually cause decreased blood clotting.

  2. Therapeutic effects
    • Rationale:

      This is not the correct answer because the therapeutic effect is the desired effect. If the healthcare provider (HCP) has prescribed warfarin for blood clotting, any over-the-counter medications should be questioned due to the potential for adverse effects. If unknowingly taken with aspirin, administration of warfarin could cause excessive, life-threatening bleeding, due to the potentiative effects.

  3. Inhibitory effects
    • Rationale:

      This is not the correct answer because inhibitory effects is a type of effect that occurs when an antagonist drug inhibits the action of an agonist drug at the same receptor. This would cause the medication to not work as desired, and cause negative effects on the client. Inhibitory effects could be desired if a person had toxic levels of a medication.

  4. Potentiative effects
    • Rationale:

      This is the correct answer because potentiative effects are ones in which one drug intensifies the effects of another. Warfarin and aspirin are both antiplatelet medications, which decreases blood clotting. Taking both medications at the same time can cause an unsafe risk for bleeding. Assessing for medications with potentiative effects is a priority nursing action.

Overview

Potentiative effects intensifies the effects of medications when given together. The nurse should be alert to assess the client’s home medications to avert the dangerous effects of potentiation.

Explanation

Learning Outcomes

Potentiative effects are ones in which one drug intensifies the effects of another. Warfarin and aspirin decrease blood clotting, and together, they increase the risk of bleeding, which is an intensified adverse effect. Potentiative effects can cause life-threatening results, so knowing and assessing for medications with this risk is a priority nursing action.

Test Taking Tip

Potentiative has the word, “potent” in it. This can remind the student that potentiative effects describe the combination of medications that can have the potential to have a “potent” effect.

Video Rationale