Pharmacology GI & Nutrition #4

Question

Which best describes sucralfate’s mechanism of action to the patient with a peptic ulcer?

Answers

  1. Fights bacteria in the stomach causing ulcers
    • Rationale:

      This answer is not correct because sucralfate is not an antibiotic, but a mucosal protectant. Antibiotics, such as amoxicillin and clarithromycin, fight Helicobacter pylori (H-pylori), a bacteria known to cause some ulcers.

  2. Suppresses acid by blocking receptors of parietal cells
    • Rationale:

      This answer is not correct because proton pump inhibitors (PPIs) suppress acid by blocking receptors of parietal cells. Sucralfate is a mucosal protectant so it coats and protects the stomach against acid. Examples of PPIs include omeprazole, esomeprazole, and lansoprazole.

  3. Coats the ulcer and protects against the effects of acid
    • Rationale:

      This answer is correct because sucralfate is a mucosal protectant designed to coat and protect the stomach from the effects of stomach acid. This medication forms a barrier to protect the stomach.

  4. Suppresses acid by inhibiting enzyme that makes gastric acid
    • Rationale:

      This answer is not correct because H2-receptor antagonists suppress acid secretion by blocking H2 receptors of the parietal cells. This medication includes cimetidine, famotidine, and ranitidine.

Overview

Sucralfate is a gastric mucosal protectant. It’s mechanism of action is to coat and protect the stomach against acid.

Explanation

Learning Outcomes

Sucralfate works to reduce the detrimental effects of acid on the gastric mucosa. It does this by coating the stomach to make the stomach not as vulnerable to acid that irritates the stomach lining and can penetrate the lining, causing peptic ulcers. The most common side effect of sucralfate is constipation. The patient should be taught ways to help prevent this side effect, such as increasing exercise, fresh fruit and vegetables, and fluids.

Test Taking Tip

Identify your problem areas that need attention. Do not waste time on restudying information you know.

Video Rationale