Pharmacology Antihypertensives #1

Question

Which serious side effect is most associated with taking an angiotensin-converting enzyme inhibitor (ACE-inhibitor)?

Answers

  1. Visual disturbances
    • Rationale:

      This answer is not correct because visual disturbance is not a side effect of ACE-inhibitors. It is a symptom of digoxin toxicity.

  2. Hypokalemia
    • Rationale:

      This answer is not correct because hypokalemia is not a side effect of ACE-inhibitors. Elevation levels of potassium is a side effect of ACE-inhibitor therapy.

  3. Leg muscle pain
    • Rationale:

      This answer is not correct because leg muscle pain is not a side effect of ACE-inhibitors. Leg muscle pain can occur in clients taking statin drugs to lower cholesterol levels. This symptom can be associated with rhabdomyolysis, a side effect of statin therapy.

  4. Swelling of the lips
    • Rationale:

      This answer is correct because swelling of the lips is a symptom of angioedema. Angioedema is a life threatening side effect of ACE-inhibitors, a common antihypertensive medication. Edema of the body occurs, including the face, lips, and throat. This is due to an allergic response to the medication. Edema in the throat is life threatening due to potential airway restriction.

Overview

Angioedema is a life threatening side effect of ACE-inhibitors, a common antihypertensive medication. Edema of the body occurs, including the face, lips, and potentially airway due to an allergic response to the medication.

Explanation

Learning Outcomes

Angioedema is swelling of the area just below the surface of the skin often associated with an allergic reaction. It most often occurs in areas of the face, lips, and throat. Sometimes edema occurs in the limbs and genitals also. Edema in the throat is life threatening due to potential airway restriction. Angioedema can result from an allergic reaction to ACE-inhibitors. African-Americans are especially susceptible to this allergic reaction.

Test Taking Tip

Focus on side effects of medications that affect the airway, breathing, or circulation of clients. These are priorities in medical care of clients.

Video Rationale