Pharmacology Antibiotics #2

Question

Which medications must patients take on an empty stomach with a full glass of water? Select all that apply.

Answers

  1. Azithromycin
    • Rationale:

      This answer is correct because azithromycin (a macrolide antibiotic) is best absorbed when taken on an empty stomach with a full glass of water. Other antibiotics that should be taken without food are levofloxacin (a fluoroquinolone antibiotic) and doxycycline (a tetracycline antibiotic). To be most effective, these classes of antibiotics should never be taken with food

  2. Cefuroxime
    • Rationale:

      This answer is not correct because food increases absorption of cefuroxime (a cephalosporin antibiotic). Patients should be taught that antibiotics should be taken as prescribed and taken completely.

  3. Levofloxacin
    • Rationale:

      This answer is correct because levofloxacin (a fluoroquinolone antibiotic) is best absorbed when taken on an empty stomach with a full glass of water. Other antibiotics that should be taken without food are azithromycin (a macrolide antibiotic) and doxycycline (a tetracycline antibiotic). To be most effective, these classes of antibiotics should never be taken with food

  4. Doxycycline
    • Rationale:

      This answer is correct because doxycycline (a tetracycline antibiotic) is best absorbed when taken on an empty stomach with a full glass of water. Other antibiotics that should be taken without food are levofloxacin (a fluoroquinolone antibiotic) and azithromycin (a macrolide antibiotic). To be most effective, these classes of antibiotics should never be taken with food

  5. Nitrofurantoin
    • Rationale:

      This answer is not correct because food increases absorption of nitrofurantoin (a nitrofuran antibiotic). Patients should be taught that antibiotics should be taken as prescribed and taken completely.

Overview

Certain antibiotics should be taken without food (on an empty stomach), with a full glass of water. Those classes of antibiotics include macrolides, fluoroquinolones, and tetracyclines.

Explanation

Learning Outcomes

Macrolide, fluoroquinolone, and tetracycline antibiotics should be taken on an empty stomach, with a full glass of water. This enhances absorption for these antibiotics. Macrolide antibiotics include azithromycin, fluoroquinolone antibiotics include levofloxacin, and tetracycline antibiotics include doxycycline. To be most effective, these antibiotics should never be taken with food.

Test Taking Tip

As you prepare for test day, try to review your notes to understand basic concepts immediately after lecture (after a very short break, of course). This 30 minutes to an hour immediately after lecture is a super productive time since it is fresh on your mind. If you do this with a friend, you can make sure you have not missed anything in your notes.

Video Rationale