Patho Patho #2


Which is considered the most classic clinical manifestation associated with osteoarthritis?


  1. Osteophytes
    • Rationale:

      This answer is correct because osteophytes are observed in clients with advanced osteoarthritis. These bony growths occur due to the damage from the inflammation of osteoarthritis causing damage to affected cartilage.

  2. Tophi
    • Rationale:

      This answer choice is not correct as tophi are associated with gout and not osteoarthritis. Tophi are the build up of uric acid that are deposited within the joints of clients with gout.

  3. Evening joint stiffness
    • Rationale:

      This answer choice is not correct as clients with osteoarthritis experience morning stiffness as opposed to evening stiffness. Joint stiffness tends to improve as the day progresses.

  4. Decreased mobility
    • Rationale:

      This answer choice is not correct as decreased mobility is not unique to osteoarthritis. Many disease processes can lead to decreased mobility. The question is asking you to identify the manifestation that is most unique to osteoarthritis.


Osteoarthritis is a progressive disease causing degenerative disease to the protective cartilage at the ends of bones. Eventually the disease results in chronic pain in the large joints such as the joints of the hands, neck, lower back, knees or hips. Osteophytes are the hallmark manifestation of osteoarthritis.


Learning Outcomes

Osteophytes are also referred to as bone spurs that occur in clients with advanced osteoarthritis. These are bony growths that develop in these clients often leading to pain in the associated joint. Osteophytes develop after long-standing osteoarthritis has caused extensive damage to the cartilage in between the joints affected by the disease.

Test Taking Tip

When studying for pathophysiology, it is essential to be able to identify manifestations that are unique to disease processes. Osteophytes are unique to osteoarthritis and are not associated with other types of arthritis as some of the other answer choices are.

Video Rationale