Endocrine Question #17


The nurse is caring for a client with hypothyroidism who receives levothyroxin daily and is scheduled for a procedure under sedation. The nurse contacts the health provider because of risk of adverse effects when administering which of the ordered medication?


  1. Benzodiazepine pre-medication
    • Rationale:
  2. Proton pump inhibitor pre-medication
    • Rationale:
  3. Benadryl pre-medication
    • Rationale:
  4. Reglan pre-medication
    • Rationale:



Benzodiazepines and hypnotic and may increase sedation and respiratory depression when taken with levothyroxine. Levothyroxine has a half-life of 6-7 days and peak in 1-3 weeks with duration of 1-3 weeks, so any procedure requiring sedation should require notification of anesthesia provider and health provider. Proton pump inhibitors, benadryl, and reglan do not pose severe reactions with levothyroxine.

Learning Outcomes

Test Taking Tip

Video Rationale