Cardiac Question #46


A client is recovering from a heart transplant and asks the nurse why he must take Cyclosporine. How should the nurse best respond?


  1. Cyclosporine decreases the risk of thrombus formation by interfering with coagulation cascade.
    • Rationale:
  2. Cyclosporine minimizes rejection of the transplant and must be taken long-term.
    • Rationale:
  3. Cyclosporine increases contractibility of the donor heart.
    • Rationale:
  4. Cyclosporine helps prevent preload and afterload dysfunction in the cardiovascular system.
    • Rationale:



Cyclosporin minimizes rejection of the transplant. After heart transplantation, proinflammatory mechanisms are recruited into the cardiac allograft and leads to rejection. The medication is usually taken for life. Generally a three-drug therapy is utilized and Cyclosporin is one of the most common drugs used. The drug does not decrease risk of thrombus, nor does it change contractibility of the donor heart or affect cardiac preload or afterload.

Learning Outcomes

Test Taking Tip

Video Rationale