Anatomy & Physiology Gastrointestinal #20


Which substance is produced by the duodenum to neutralize the acidity of stomach acids in the digestive process?


  1. Bile
    • Rationale:

      Bile is produced by the liver and stored in the gallbladder. It is not produced by the duodenum to neutralize stomach acids in the digestive process.

  2. Protease
    • Rationale:

      Any enzyme that breaks down protein into amino acids during the digestive process is referred to as protease. There are three primary proteases: chymotrypsin, pepsin, and trypsin.

  3. Amylase
    • Rationale:

      Amylase is an enzyme that is primarily found in the saliva and pancreatic fluid. It is responsible for converting glycogen and starches into simple sugars that are used for fuel within the body.

  4. Bicarbonate
    • Rationale:

      The duodenum produces bicarbonate. Bicarbonate is an alkaline substance that assists in the neutralization of the acidic content of the chyme, or partially digested fluids and foods that move through the GI tract during the digestive process.


The duodenum is a structure of the large intestine. It connects to the stomach at its upper end and to the jejunum at its lower end.


Learning Outcomes

The duodenum does not play as large of a role in absorption when compared to the jejunum and the ileum of the small intestine. However, the duodenum plays an important role in the digestive process as it is primarily responsible for the absorption of iron. Iron helps form, and oxygenate, blood cells within the body.

Test Taking Tip

Consider each choice and ask yourself, “Is this a substance produced by the duodenum?” The choice that you answer with a yes is the correct one.

Video Rationale